<b>Introduction</b>

We discuss multiple <span>aspects of the
immuno-inflammatory host reaction, which results in loss of alveolar bone
ultimately in this review. Based on the formulated proposal, periodontal
inflammation interferes with the uncoupling of bone desorption that is
consistent with the process of a pathologic and formation while stimulating
osteoclastogenesis. Experimental animal models based arguments suggest an
important function of temporal and spatial dimensions of inflammation in the
periodontium. There is a new paradigm to help in explaining the full impact of
inflammation on alveolar bone in the periodontal disease based on the review of
these findings, which is to include of inflammation on uncoupling of bone
formation from resorption</span>

- Role of sirtuins in periodontal inflammation

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