Formulation and In vitro Evaluation of Eudragit RL 100 Loaded Fexofenadine HCl Microspheres

Posted: 8 months ago
The present study deals with the formulation and evaluation of Fexofenadine hydrochloride (HCl) loaded
sustained-release microspheres by emulsion solvent evaporation method with Eudragit RL 100. The effects of
percent drug loading on drug encapsulation efficiency, drug content and drug release rate were assessed. In
vitro dissolution study was performed spectrophotometrically according to the USP paddle method using
phosphate buffer (pH 6.8) for 10 hours. The release rate of Fexofenadine HCl from the microspheres was
significantly increased with the increase of drug loading. The drug release patterns were simulated in
different kinetic orders such as zero-order release kinetics, first-order release kinetics, Higuchi release
kinetics, Korsmeyer-Peppas release kinetics, and Hixson-Crowell release kinetics to assess the release
mechanism and Higuchi release kinetics was found to be the predominant release mechanism. Morphological
changes due to different drug loading were assessed by scanning electron microscopic (SEM) technique.
Differential scanning calorimetry and Fourier transform infrared (FT-IR) spectroscopy was performed to
evaluate the compatibility of the drug with the polymer. A statistically significant variation in drug encapsulation
efficiency and release rate was observed for variation in drug loading.
Keywords: Emulsification-solvent evaporation, fexofenadine HCl, eudragit RL 100, microsphere