<div><br></div><div>Arefin et al. SpringerPlus (2016) 5:691<br>DOI 10.1186/s40064-016-2322-2<br></div><div><br></div><div>Abstract:<br></div><div><br></div><div>The aim of the current study was to formulate Fexofenadine hydrochloride loaded</div>sustained release microspheres using HPMC K100 M CR, a release retardant hydrophilic<br>polymer by solvent evaporation method. The effect of different drug loading on drug<br>content, drug encapsulation efficiency and release of drug was monitored. The studies<br>on in vitro release mechanism were performed using USP paddle method with 900 ml<br>of phosphate buffer (pH 6.8) for 10 h at 100 rpm. The mechanism of the drug release<br>was determined by fitting in vitro release data to various release kinetic models such<br>as the zero order, first order, Higuchi, Hixson Crowell and Korsemeyer–Peppas model<br>and finding R2 values for the release profile corresponding to each model. The results<br>confirm that the release rate of the drug from the microspheres is highly affected by<br>the drug to polymer ratio. The study finds that Higuchi release kinetics, Korsmeyer–<br>Peppas release kinetics and Hixson–Crowell release kinetics were the major release<br>mechanism. The release mechanism was found to be non-Fickian with increase of<br>polymer content. Scanning electron microscopic technique was performed to obtain<br>the morphological changes due to different drug loading. Differential scanning calorimetry<br>and Fourier transform infra-red spectroscopy was performed to determine any<br>interaction of drug with the polymer. A statistically significant variation in release rate<br>was observed for variation in the amount of HPMC K100 M CR. In the present study, a<br>series of sustained release formulations of Fexofenadine hydrochloride were developed<br>with different drug loading so that these formulations could further be evaluated from<br>the in vivo studies. The formulations were found to be stable and reproducible.<br>Keywords: Emulsification-solvent evaporation, Fexofenadine HCl, Microsphere<br><br>

Fexofenadine HCl microspheres with HPMC K100 MCR Polymer Springerplus Open Access

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