<div><br></div><div>This is a research article published in Bangladesh Pharmaceutical Journal 19(1)<br></div><div><br></div><div>Abstract:<br></div><div><br></div><div>The present study deals with the formulation and evaluation of Fexofenadine hydrochloride (HCl) loaded</div>sustained release microspheres by emulsion solvent evaporation method with Eudragit RL 100. The effects of<br>percent drug loading on drug encapsulation efficiency, drug content and drug release rate were assessed. In<br>vitro dissolution study was performed spectrophotometrically according to USP paddle method using<br>phosphate buffer (pH 6.8) for 10 hours. The release rate of Fexofenadine HCl from the microspheres was<br>significantly increased with the increase of drug loading. The drug release patterns were simulated in<br>different kinetic orders such as zero order release kinetics, first order release kinetics, Higuchi release<br>kinetics, Korsmeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release<br>mechanism and Higuchi release kinetics was found to be the predominant release mechanism. Morphological<br>changes due to different drug loading were assessed by scanning electron microscopic (SEM) technique.<br>Differential scanning calorimetry and fourier transform infra-red (FT-IR) spectroscopy was performed to<br>evaluate compatibility of drug with the polymer. A statistically significant variation indrug encapsulation<br>efficiency and release rate was observed for variation in drug loading.<br><br>

Fexofenadine HCl microspheres with Eudragit RL 100 Polymer

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